华法林与肠道中抗酸成分的相互作用。
The interaction of warfarin with antacid constituents in the gut.
作者信息
McElnay J C, Harron D W, D'Arcy P F, Collier P S
出版信息
Experientia. 1979 Oct 15;35(10):1359-60. doi: 10.1007/BF01964007.
PMID:499421
Abstract
A study was made of the effect of 4 constituents of antacid preparations on the absorption of the coumarin derivate warfarin sodium using an in vitro experimental model. The constituents tested were activated dimethiocone (a silicone) magnesium trisilicate, bismuth carbonate and the adsorbant, kaolin. Slight decreased intestinal absorption was shown by magnesium trisilicate (19%) and bismuth carbonate (7%), the other 2 components showing no effects.
摘要
利用体外实验模型，研究了抗酸剂制剂的4种成分对香豆素衍生物华法林钠吸收的影响。所测试的成分有活性二甲硅油（一种硅酮）、三硅酸镁、碳酸铋和吸附剂高岭土。三硅酸镁（19%）和碳酸铋（7%）使肠道吸收略有下降，其他两种成分无影响。
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