Konícková L, Prát V
J Clin Pathol. 1971 Mar;24(2):113-6. doi: 10.1136/jcp.24.2.113.
The therapeutic efficacy of a combination of gentamicin with carbenicillin was compared with those of each antibiotic alone. The efferent urinary ducts of rats were infected with Pseudomonas aeruginosa and antibiotic therapy was started six days later. After seven days' therapy quantitative bacteriological findings in the urine and renal tissue were compared with those of untreated rats that had been infected. The degree of infection was least in the group treated with concurrent gentamicin and carbenicillin. It was concluded that the therapeutic efficacy of the gentamicin-carbenicillin combination exceeded those of each antibiotic administered alone.
将庆大霉素与羧苄青霉素联合使用的治疗效果与单独使用每种抗生素的效果进行了比较。将大鼠的输出尿道感染铜绿假单胞菌，六天后开始抗生素治疗。经过七天的治疗后，将尿液和肾组织中的定量细菌学结果与未治疗的感染大鼠的结果进行比较。同时使用庆大霉素和羧苄青霉素治疗的组感染程度最轻。得出的结论是，庆大霉素-羧苄青霉素联合使用的治疗效果超过单独使用每种抗生素的效果。
