新型氨基糖苷类抗生素奈替米星的体外协同作用
In vitro synergistic effect of netilmicin, a new aminoglycoside antibiotic.
作者信息
Fu K P, Neu H C
出版信息
Antimicrob Agents Chemother. 1976 Sep;10(3):511-8. doi: 10.1128/AAC.10.3.511.
The combination of netilmicin (Sch 20569) with carbenicillin, cefazolin, chloramphenicol, and clindamycin was evaluated by in vitro tests against 91 clinical isolates of Pseudomonas, Klebsiella, and Escherichia coli. Combinations were considered to show synergy if there was a fourfold or greater reduction in minimal inhibitory concentration values of both antibiotics when combined. Synergy of netilmicin with carbenicillin could be demonstrated against 21 of 46 Pseudomonas isolates. Comparison of the synergy of carbenicillin with netilmicin or gentamicin showed that netilmicin was less active than gentamicin against Pseudomonas aeruginosa. However, at therapeutic concentrations of the antibiotics, significant differences were not observed. Synergy of netilmicin and cefazolin was demonstrated against only 1 of 21 Klebsiella strains tested, but partial synergy was found for 12 of 20 isolates. Synergy and antagonism were uncommon with the netilmicin-chloramphenicol and netilmicin-clindamycin combinations against E. coli and Pseudomonas.
通过体外试验，对91株临床分离的假单胞菌属、克雷伯菌属和大肠杆菌进行了奈替米星（Sch 20569）与羧苄西林、头孢唑林、氯霉素和克林霉素联合用药的评估。如果两种抗生素联合使用时最低抑菌浓度值降低四倍或更多，则认为联合用药具有协同作用。奈替米星与羧苄西林联合用药对46株假单胞菌属分离株中的21株可显示协同作用。羧苄西林与奈替米星或庆大霉素联合用药的协同作用比较表明，奈替米星对铜绿假单胞菌的活性低于庆大霉素。然而，在抗生素的治疗浓度下，未观察到显著差异。奈替米星与头孢唑林联合用药仅对21株受试克雷伯菌属菌株中的1株显示协同作用，但对20株分离株中的12株发现有部分协同作用。奈替米星与氯霉素和奈替米星与克林霉素联合用药对大肠杆菌和假单胞菌属的协同作用和拮抗作用并不常见。
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