头孢甘氨酸及其生物活性代谢物去乙酰头孢甘氨酸。
Cephaloglycin and its biologically active metabolite desacetylcephaloglycin.
作者信息
Wick W E, Wright W E, Kuder H V
出版信息
Appl Microbiol. 1971 Mar;21(3):426-34. doi: 10.1128/am.21.3.426-434.1971.
Abstract
Chromatographic studies and microbiological assays show that, after oral administration, cephaloglycin is partially converted in man to a biologically active metabolite desacetylcephaloglycin. The antibacterial activity of this metabolite compared to that of cephaloglycin is equivalent against gram-positive organisms but is lower against gram-negative bacilli. Successful therapy of urinary tract infections with cephaloglycin must be mainly attributed to the antibacterial activity of this metabolite. At the present time, it is not possible to assess what influence low amounts of unaltered cephaloglycin have on the outcome of therapy.
摘要
色谱研究和微生物测定表明，口服后，头孢甘氨酸在人体内部分转化为具有生物活性的代谢产物去乙酰头孢甘氨酸。与头孢甘氨酸相比，这种代谢产物对革兰氏阳性菌的抗菌活性相当，但对革兰氏阴性杆菌的抗菌活性较低。头孢甘氨酸成功治疗尿路感染主要归因于这种代谢产物的抗菌活性。目前，尚无法评估少量未改变的头孢甘氨酸对治疗结果有何影响。
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