头孢菌素在马血清中的稳定性。
Stability of cephalosporins in horse serum.
作者信息
Foglesong M A
出版信息
Antimicrob Agents Chemother. 1977 Jan;11(1):174-5. doi: 10.1128/AAC.11.1.174.
The antibiotic activity of cephalothin, cephaloridine, cephalexin, cephaloglycin, cefazolin, and cefamandole was determined after storage for up to 30 days in horse serum at -10 and 4 degrees C. Cephalothin, cefamandole, cefazolin, and cephalexin were stable for at least 30 days at -10 degrees C, whereas cephaloridine lost 29% of its initial activity and cephaloglycin lost more than 50%. Cefamandole, cefazolin, and cephalexin could only be stored for 3 days at 4 degrees C without significant loss in activity, whereas cephalothin, cephaloridine, and cephaloglycin could be stored for only 1 day. Repeated freezing and thawing had a detrimental effect on the stability of cephaloridine.
在-10℃和4℃的马血清中储存长达30天后，测定了头孢噻吩、头孢噻啶、头孢氨苄、头孢甘氨酸、头孢唑林和头孢孟多的抗生素活性。头孢噻吩、头孢孟多、头孢唑林和头孢氨苄在-10℃下至少稳定30天，而头孢噻啶损失了其初始活性的29%，头孢甘氨酸损失超过50%。头孢孟多、头孢唑林和头孢氨苄在4℃下只能储存3天而活性无显著损失，而头孢噻吩、头孢噻啶和头孢甘氨酸只能储存1天。反复冻融对头孢噻啶的稳定性有不利影响。
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