Wright W E, Frogge J A
Antimicrob Agents Chemother. 1980 Jan;17(1):99-100. doi: 10.1128/AAC.17.1.99.
Cephalosporins having a 3-acetoxymethyl group are hydrolyzed to the corresponding desacetyl derivative by lysed whole blood but not by plasma or serum. When bioassays for this important class of cephalosporins must be run in whole blood or on tissues containing whole blood, steps should be taken to assure that the influence of the whole blood on the bioassay is properly interpreted.
具有3-乙酰氧甲基的头孢菌素会被裂解的全血水解为相应的去乙酰衍生物，但不会被血浆或血清水解。当必须在全血中或含有全血的组织上对这类重要的头孢菌素进行生物测定时，应采取措施确保正确解读全血对生物测定的影响。
