Barbieri R L, Evans S, Kistner R W
Fertil Steril. 1982 Jun;37(6):737-46. doi: 10.1016/s0015-0282(16)46331-4.
A prospective study to evaluate the efficacy of danazol in the treatment of endometriosis was initiated in 1976. One hundred patients with endometriosis, as demonstrated by laparoscopy, were entered into the study. The mean length of patient follow-up was 49 months. All patients were treated with 800 mg of danazol per day. The mean duration of danazol therapy was 17.3 weeks. Eighty-nine percent of the patients reported symptomatic improvement, and 94% were improved, as demonstrated by repeat laparoscopy or laparatomy. After completing a course of danazol therapy, 57% of the patients underwent conservative laparotomy for fertility enhancement, pain control, or ovarian masses. Two patients underwent total abdominal hysterectomy-bilateral salpingo-oophorectomy for advanced disease poorly responsive to danazol therapy. In those patients desiring fertility (56), there were 38 pregnancies in 26 women, for an overall fertility rate of 46%. The overall recurrence rate was 33%, as determined by symptoms and physical findings. Significant side effects from danazol were reported by 85% of the patients. The major side effects were weight gain, edema, decrease in breast size, oily skin, hirsutism, and deepening of the voice. Only one patient discontinued danazol therapy due to side effects. Clinical tissues concerning the use of danazol with or without surgery and the miscarriage rate following danazol therapy are discussed.
1976年开展了一项前瞻性研究，以评估达那唑治疗子宫内膜异位症的疗效。100例经腹腔镜检查证实患有子宫内膜异位症的患者进入该研究。患者的平均随访时间为49个月。所有患者均接受每日800毫克达那唑的治疗。达那唑治疗的平均持续时间为17.3周。89%的患者报告症状改善，经重复腹腔镜检查或剖腹手术证实，94%的患者病情得到改善。完成一个疗程的达那唑治疗后，57%的患者接受了保守性剖腹手术，以提高生育能力、控制疼痛或处理卵巢肿块。两名患者因对达那唑治疗反应不佳的晚期疾病接受了全腹子宫切除术-双侧输卵管卵巢切除术。在那些希望生育的患者（56例）中，26名女性中有38次妊娠，总体生育率为46%。根据症状和体格检查结果确定的总体复发率为33%。85%的患者报告了达那唑的显著副作用。主要副作用包括体重增加、水肿、乳房变小、皮肤油腻、多毛症和声音变低沉。只有一名患者因副作用停止了达那唑治疗。讨论了关于达那唑联合或不联合手术使用以及达那唑治疗后流产率的临床资料。
