急性肾盂肾炎婴幼儿和儿童中针对大肠杆菌O抗原的沉淀抗体的特性分析
Characterization of precipitating antibodies to E. coli O antigen in infants and children with acute pyelonephritis.
作者信息
Hanson L A, Holmgren J, Jodal U, Kaijser B
出版信息
Clin Exp Immunol. 1971 Apr;8(4):573-80.
Abstract
Precipitating serum antibodies to O antigens from some infants and children with acute pyelonephritis were studied. These precipitins were largely resistant to reduction with 2-mercaptoethanol and were localized in the 7S fraction after gel filtration of the patient sera through Sephadex G-200. The precipitins were inhibited by anti-IgG serum, but not by anti-IgA or -IgM sera using a combined single and double diffusion method. The IgG nature of the precipitins investigated was also substantiated by immunofluorescence studies of precipitates formed by O antigens and the corresponding antibodies in double diffusion plates. Possible reasons for the occurrence of IgG precipitins predominantly in patients with recurrent attacks of pyelonephritis are discussed.
摘要
对一些患有急性肾盂肾炎的婴幼儿血清中针对O抗原的沉淀抗体进行了研究。这些沉淀素在很大程度上对2-巯基乙醇的还原具有抗性，并且在通过Sephadex G-200对患者血清进行凝胶过滤后定位于7S组分中。采用单扩散和双扩散联合方法，沉淀素被抗IgG血清抑制，但不被抗IgA或抗IgM血清抑制。通过对双扩散板中O抗原与相应抗体形成的沉淀物进行免疫荧光研究，也证实了所研究沉淀素的IgG性质。文中讨论了在复发性肾盂肾炎患者中主要出现IgG沉淀素的可能原因。
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