IgG单克隆丙种球蛋白病中的重链分型，特别提及血清高粘度和冷球蛋白血症病例。
Heavy chain typing in IgG monoclonal gammopathies with special reference to cases of serum hyperviscosity and cryoglobulinaemia.
作者信息
Virella G, Hobbs J R
出版信息
Clin Exp Immunol. 1971 Jun;8(6):973-80.
Abstract
Heavy chain subclasses of 121 IgG monoclonal proteins were found to be 74% IgG, 10% IgG, 12% IgG and 4% IgG. Light chain subclasses showed a slight kappa excess among IgG proteins. Electrophoretic studies of these monoclonal proteins and of normal γ-globulin showed IgG had a wide range of mobility including the most slow (electronegative) proteins; IgG and IgG were among the faster moving, while IgG showed medium to slow mobility. The above random distribution of IgG subclasses was found in eighteen monoclonal proteins causing hyperviscosity syndrome, whereas among fourteen monoclonal cryoglobulins there was an excess of IgG and IgG subclasses.
摘要
在121种IgG单克隆蛋白中，重链亚类发现为74%的IgG₁、10%的IgG₂、12%的IgG₃和4%的IgG₄。轻链亚类在IgG蛋白中显示κ链略占优势。对这些单克隆蛋白和正常γ球蛋白进行的电泳研究表明，IgG具有广泛的迁移率，包括迁移最慢（带负电）的蛋白；IgG₁和IgG₃迁移较快，而IgG₂显示中等至较慢的迁移率。上述IgG亚类的随机分布在18种导致高黏滞综合征的单克隆蛋白中被发现，而在14种单克隆冷球蛋白中，IgG₁和IgG₃亚类过多。
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本文引用的文献
1
TWO TYPES OF gamma-MYELOMA PROTEINS, beta(2A)-MYELOMA PROTEINS, gamma(1)-MACROGLOBULINS, AND BENCE JONES PROTEINS IDENTIFIED BY TWO GROUPS OF COMMON ANTIGENIC DETERMINANTS.两类γ-骨髓瘤蛋白、β(2A)-骨髓瘤蛋白、γ(1)-巨球蛋白以及由两组共同抗原决定簇鉴定出的本斯·琼斯蛋白。
J Clin Invest. 1963 Jun;42(6):811-22. doi: 10.1172/JCI104773.
2
SERUM HYPERVISCOSITY SYNDROME.血清高黏滞综合征
JAMA. 1965 May 10;192:464-7. doi: 10.1001/jama.1965.03080190030008.
3
H CHAIN SUBGROUPS OF MYELOMA PROTEINS AND NORMAL 7S GAMMA-GLOBULIN.骨髓瘤蛋白和正常7Sγ球蛋白的重链亚群
J Exp Med. 1964 Aug 1;120(2):253-66. doi: 10.1084/jem.120.2.253.
4
GAMMA GLOBULIN ANTIGENIC TYPES DEFINED BY HEAVY CHAIN DETERMINANTS.由重链决定簇定义的γ球蛋白抗原类型。
Science. 1964 Jul 10;145(3628):168-70. doi: 10.1126/science.145.3628.168.
5
Reduction of gamma-globulins.γ球蛋白减少
Arch Biochem Biophys. 1962 Sep;Suppl 1:174-80.
6
Three gamma-globulins in normal human serum revealed by monkey precipitins.
Science. 1960 Nov 4;132(3436):1313-4. doi: 10.1126/science.132.3436.1313.
7
The basis of the erythrocyte sedimentation rate.红细胞沉降率的基础。
Clin Sci. 1952 Nov;11(4):333-55.
8
Aggregation of gamma-G3 proteins: relevance to the hyperviscosity syndrome.γ-G3蛋白的聚集：与高黏滞综合征的相关性
J Clin Invest. 1970 Mar;49(3):610-21. doi: 10.1172/JCI106272.
9
The hyperviscosity syndrome. I. In IgG myeloma. The role of protein concentration and molecular shape.高黏滞综合征。I. IgG 型骨髓瘤。蛋白质浓度和分子形状的作用。
J Clin Invest. 1970 Jan;49(1):15-20. doi: 10.1172/JCI106213.
10
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