用于诊断对洗涤产品中所用酶的过敏反应的点刺试验和血清学试验。

Prick-tests and serological tests in the diagnosis of allergic reactivity to enzymes used in washing products.

作者信息

How M J, Cambridge G W

出版信息

Br J Ind Med. 1971 Jul;28(3):303-7. doi: 10.1136/oem.28.3.303.

DOI:10.1136/oem.28.3.303

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1069506/

Abstract

303-307. Standardized prick-test antigens for use in the detection of allergic reactivity to enzymes (Alcalase and Maxatase) used in washing products have been prepared. These materials contained all the potentially allergenic components of the crude enzyme preparations. Tests showed that these materials were more appropriate, as prick-test antigens, than the crystalline enzyme. The presence of reagin-mediated, immediate-type allergy in factory workers was confirmed by prick-tests and passive transfer tests. Sera from these subjects and controls contained enzyme-specific haemagglutinating antibody and gave precipitin-like reactions with solutions of Alcalase and Maxatase. The latter reaction involved serum components electrophoretically similar to, or identical with, α-globulins.

摘要

303 - 307. 已制备出用于检测对洗涤产品中使用的酶（碱性蛋白酶和嗜热菌蛋白酶）过敏反应的标准化点刺试验抗原。这些材料包含粗酶制剂中所有潜在的过敏原成分。试验表明，作为点刺试验抗原，这些材料比结晶酶更合适。通过点刺试验和被动转移试验证实了工厂工人中存在反应素介导的速发型过敏。这些受试者和对照组的血清含有酶特异性血凝抗体，并与碱性蛋白酶和嗜热菌蛋白酶溶液发生沉淀样反应。后一种反应涉及电泳上与α球蛋白相似或相同的血清成分。

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引用本文的文献

1

Lung function, atopy, specific hypersensitivity, and smoking of workers in the enzyme detergent industry over 11 years.

Br J Ind Med. 1985 Jan;42(1):43-50. doi: 10.1136/oem.42.1.43.

2

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3

Biological effects of proteolytic enzyme detergents.

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