Battifora H, Applebaum E L
Head Neck Surg. 1979 Jan-Feb;1(3):202-12. doi: 10.1002/hed.2890010303.
Six patients with malignant head and neck tumors are shown to have required electron microscopy for accurate diagnosis. In all of these tumors, there were ultrastructural features of cytodifferentiation that were not discernible by light microscopy, such as neurosecretory granules, desmosomes, cytoplasmic processes, tonofibrils, and myofilaments. Electron microscopy is helpful in the differential diagnosis of tumors in general, but its effectiveness is particularly apparent in small-cell "undifferentiated" tumors such as neuroblastoma, rhabdomyosarcoma, Ewing's sarcoma, undifferentiated squamous-cell carcinoma of the lymphoepithelioma type, and malignant lymphoma. It has also been helpful in the identification of amelanotic melanoma and spindle-cell carcinoma.
六例恶性头颈部肿瘤患者经证实需要借助电子显微镜进行准确诊断。在所有这些肿瘤中，存在光镜下无法辨别的细胞分化超微结构特征，如神经分泌颗粒、桥粒、细胞质突起、张力原纤维和肌丝。电子显微镜总体上有助于肿瘤的鉴别诊断，但其有效性在小细胞“未分化”肿瘤中尤为明显，如神经母细胞瘤、横纹肌肉瘤、尤因肉瘤、淋巴上皮瘤型未分化鳞状细胞癌和恶性淋巴瘤。它在无黑色素性黑色素瘤和梭形细胞癌的识别中也有帮助。
