Ghadially F N
Diagn Histopathol. 1981 Jul-Sep;4(3):245-62.
In the majority of cases the histogenesis and classification of tumours can be unequivocally established by light microscopy, but in some instances the diagnosis remains ambiguous even after special staining techniques have been employed. So wide and varied are the situations in which the electron microscope can help establish a diagnosis that it is impossible to even mention them all in the brief time available. I will therefore present only a brief description of the manner in which one can resolve with the electron microscopy some well known diagnostic problems. This includes distinguishing: (1) an anaplastic carcinoma from a sarcoma; (2) an amelanotic melanoma from other tumours; (3) APUDomas from other tumors; (4) myosarcomas from other tumours; and (5) Ewing's tumour, neuroblastoma and lymphoma from each other.
在大多数情况下，肿瘤的组织发生和分类可通过光学显微镜明确确定，但在某些情况下，即使采用了特殊染色技术，诊断仍不明确。电子显微镜有助于诊断的情况广泛多样，以至于在有限的时间内甚至无法全部提及。因此，我将仅简要描述如何通过电子显微镜解决一些众所周知的诊断问题。这包括区分：（1）未分化癌与肉瘤；（2）无黑色素的黑色素瘤与其他肿瘤；（3）APUD瘤与其他肿瘤；（4）肌肉肉瘤与其他肿瘤；以及（5）尤因肉瘤、神经母细胞瘤和淋巴瘤。
