热与电离辐射对病毒的协同灭活作用。

Synergistic inactivation of viruses by heat and ionizing radiation.

作者信息

Trujillo R, Dugan V L

出版信息

Biophys J. 1972 Jan;12(1):92-113. doi: 10.1016/S0006-3495(72)86073-9.

DOI:10.1016/S0006-3495(72)86073-9

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1484081/

Abstract

Viral inactivation by heat and/or ionizing radiation is analyzed in terms of a kinetic model. The phenomenon of synergistic viral inactivation observed when viruses are exposed to the simultaneous application of heat and ionizing radiation is interpreted within the framework provided by this three-term model. Data on the inactivation of T4 bacteriophage by heat and/or ionizing radiation is presented, and the kinetic model is used to provide a description of observed dose rate and temperature dependences. Extension of the model to other viral systems inactivated by heat and ionizing radiation is considered, and the general applicability of these analyses suggests that the kinetic model may well serve as an extension of target theory in describing the radiobiological effects of ionizing radiation.

摘要

通过动力学模型分析了热和/或电离辐射对病毒的灭活作用。当病毒同时暴露于热和电离辐射时所观察到的协同病毒灭活现象，在这个三项模型所提供的框架内进行了解释。给出了关于T4噬菌体被热和/或电离辐射灭活的数据，并使用动力学模型来描述所观察到的剂量率和温度依赖性。考虑了将该模型扩展到其他被热和电离辐射灭活的病毒系统，这些分析的普遍适用性表明，动力学模型很可能作为靶理论的扩展，用于描述电离辐射的放射生物学效应。

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