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1
Biologic activity of digoxin-specific antisera.地高辛特异性抗血清的生物活性。
J Clin Invest. 1972 Mar;51(3):638-48. doi: 10.1172/JCI106853.
2
Effects of digoxin-specific antibodies on accumulation and binding of digoxin by human erythrocytes.地高辛特异性抗体对人红细胞摄取和结合地高辛的影响。
J Clin Invest. 1973 Aug;52(8):1820-33. doi: 10.1172/JCI107364.
3
The isolation of digoxin-specific antibody and its use in reversing the effects of digoxin.地高辛特异性抗体的分离及其在逆转地高辛作用方面的应用。
Proc Natl Acad Sci U S A. 1971 Oct;68(10):2401-6. doi: 10.1073/pnas.68.10.2401.
4
Persistence of hapten-antibody complexes in the circulation of immunized animals after a single intravenous injection of hapten.在给免疫动物单次静脉注射半抗原后，半抗原 - 抗体复合物在其循环系统中的持续存在情况。
J Exp Med. 1974 Feb 1;139(2):278-94. doi: 10.1084/jem.139.2.278.
5
Digoxin: immunologic approaches to measurement and reversal of toxicity.地高辛：毒性测定与解毒的免疫学方法
N Engl J Med. 1970 Nov 19;283(21):1150-6. doi: 10.1056/NEJM197011192832109.
6
Serum digoxin by radioimmunoassay.采用放射免疫分析法测定血清地高辛。
Can Med Assoc J. 1971 Jul 24;105(2):170-3.
7
Correlation of the subcellular distribution of digoxin with the positive inotropic effect.地高辛的亚细胞分布与正性肌力作用的相关性。
J Pharmacol Exp Ther. 1972 May;181(2):377-85.
8
Renal handling and effects of [3H]digoxin and interactions with quinidine in the avian kidney.[3H]地高辛在禽类肾脏中的肾处理、作用及其与奎尼丁的相互作用
Acta Physiol Scand. 1986 May;127(1):9-16. doi: 10.1111/j.1748-1716.1986.tb07869.x.
9
Characterization of antibodies of high affinity and specificity for the digitalis glycoside digoxin.对洋地黄糖苷地高辛具有高亲和力和特异性的抗体的表征。
Biochemistry. 1970 Jan 20;9(2):331-7. doi: 10.1021/bi00804a020.
10
Digoxin-specific antibodies.地高辛特异性抗体。
Proc Natl Acad Sci U S A. 1967 Jan;57(1):71-8. doi: 10.1073/pnas.57.1.71.

引用本文的文献

1
Pharmacokinetic aspects of digoxin-specific Fab therapy in the management of digitalis toxicity.地高辛特异性Fab片段疗法治疗洋地黄中毒的药代动力学方面
Clin Pharmacokinet. 1995 Jun;28(6):483-93. doi: 10.2165/00003088-199528060-00006.
2
Monoclonal digoxin-specific antibodies induce dose- and affinity-dependent plasma digoxin redistribution in rats.单克隆地高辛特异性抗体在大鼠中诱导剂量和亲和力依赖性的血浆地高辛重新分布。
Pharm Res. 1995 May;12(5):709-14. doi: 10.1023/a:1016211626095.
3
Effect of quinidine on the digoxin receptor in vitro.奎尼丁对体外地高辛受体的作用。
J Clin Invest. 1981 Oct;68(4):1065-74. doi: 10.1172/jci110329.
4
Effects of digoxin-specific antibodies on accumulation and binding of digoxin by human erythrocytes.地高辛特异性抗体对人红细胞摄取和结合地高辛的影响。
J Clin Invest. 1973 Aug;52(8):1820-33. doi: 10.1172/JCI107364.
5
Reversal of ouabain and acetyl strophanthidin effects in normal and failing cardiac muscle by specific antibody.特异性抗体对哇巴因和乙酰毒毛旋花子苷在正常及衰竭心肌中作用的逆转
J Clin Invest. 1974 Jun;53(6):1655-61. doi: 10.1172/JCI107716.
6
Persistence of hapten-antibody complexes in the circulation of immunized animals after a single intravenous injection of hapten.在给免疫动物单次静脉注射半抗原后，半抗原 - 抗体复合物在其循环系统中的持续存在情况。
J Exp Med. 1974 Feb 1;139(2):278-94. doi: 10.1084/jem.139.2.278.
7
The influence of digoxin antibodies on digoxin disposition and effect: studies in guinea-pigs and HeLa cells.地高辛抗体对地高辛处置及效应的影响：豚鼠和人宫颈癌细胞系（HeLa细胞）研究
Br J Pharmacol. 1985 Jan;84(1):157-63.
8
Reversal of advanced digitoxin toxicity and modification of pharmacokinetics by specific antibodies and Fab fragments.特异性抗体及Fab片段对严重洋地黄毒苷中毒的逆转作用及药代动力学的改变
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9
Effects of sheep digoxin-specific antibodies and their Fab fragments on digoxin pharmacokinetics in dogs.羊地高辛特异性抗体及其Fab片段对犬地高辛药代动力学的影响。
J Clin Invest. 1977 Feb;59(2):345-59. doi: 10.1172/JCI108647.

本文引用的文献

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Binding of hormone to tissue: the first step in polypeptide hormone action.激素与组织的结合：多肽激素作用的第一步。
Proc Natl Acad Sci U S A. 1966 Dec;56(6):1802-9. doi: 10.1073/pnas.56.6.1802.
2
Extracellular space estimation in rat kidney slices using C saccharides and phlorizin.使用C糖类和根皮苷对大鼠肾切片进行细胞外空间估计。
Am J Physiol. 1962 Apr;202:800-4. doi: 10.1152/ajplegacy.1962.202.4.800.
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Transport of amino acids by slices of rat-kidney cortex.大鼠肾皮质切片对氨基酸的转运
Biochim Biophys Acta. 1961 Dec 23;54:479-88. doi: 10.1016/0006-3002(61)90088-9.
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MEASUREMENT OF LOW ENERGY BETA-EMITTERS IN AQUEOUS SOLUTION BY LIQUID SCINTILLATION COUNTING OF EMULSIONS.通过乳液的液体闪烁计数法测量水溶液中的低能β发射体。
Anal Chem. 1965 Jun;37:854-7. doi: 10.1021/ac60226a017.
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ISOLATION OF 7S AND 19S GAMMA GLOBULINS.7S和19Sγ球蛋白的分离
Methods Med Res. 1964;10:80-6.
6
EQUILIBRIUM DIALYSIS FOR MEASUREMENT OF ANTIBODY-HAPTEN AFFINITIES.用于测量抗体-半抗原亲和力的平衡透析法。
Methods Med Res. 1964;10:106-14.
7
A STUDY OF THE CROSS-REACTIVITY OF ANTIPURIN-6-OYL SERUM WITH DEOXYRIBONUCLEIC ACID (DNA).抗嘌呤 - 6 - 酰基血清与脱氧核糖核酸（DNA）交叉反应性的研究
J Exp Med. 1965 Jan 1;121(1):19-38. doi: 10.1084/jem.121.1.19.
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THE ACTION OF CARDIAC GLYCOSIDES ON ION MOVEMENTS.强心苷对离子运动的作用。
Pharmacol Rev. 1964 Dec;16:381-407.
9
ANTIBODIES SPECIFIC FOR RIBONUCLEOSIDES AND RIBONUCLEOTIDES AND THEIR REACTION WITH DNA.对核糖核苷和核糖核苷酸具有特异性的抗体及其与DNA的反应。
Proc Natl Acad Sci U S A. 1964 Jul;52(1):68-74. doi: 10.1073/pnas.52.1.68.
10
FURTHER STUDIES ON THE BIOLOGICAL EFFECTS OF PASSIVE IMMUNIZATION WITH ANTIBODIES TO STEROID-PROTEIN CONJUGATES.关于用类固醇 - 蛋白质结合物抗体进行被动免疫的生物学效应的进一步研究。
Endocrinology. 1964 Apr;74:593-8. doi: 10.1210/endo-74-4-593.

地高辛特异性抗血清的生物活性。

Biologic activity of digoxin-specific antisera.

作者信息

Watson J F, Butler V P

出版信息

J Clin Invest. 1972 Mar;51(3):638-48. doi: 10.1172/JCI106853.

DOI:10.1172/JCI106853
PMID:5011105
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC302170/
Abstract

Digoxin-specific antibodies are capable of removing essentially all intracellular digoxin from rat renal cortical slices or from human erythrocytes. In removing digoxin from erythrocytes, these antibodies are capable of reversing an effect of the drug on cellular potassium transport. This study provides direct evidence that antibodies are capable of removing, and thereby reversing the biological effect of, physiologically active low molecular weight substances after they have been taken up by mammalian cells. This biologic property of digoxin-specific antibodies suggests that autidigoxin sera may prove useful in the reversal of digoxin toxicity. Rapid and essentially quantitative removal of digoxin from red cells by antibody is not accompanied by an immediate restoration of patassium influx to normal levels. Identification of the mechanism of this phenomenon may provide useful information concerning the mode of action not only of digoxin, but also of the cation transport system of human erythrocytes.

摘要

地高辛特异性抗体能够从大鼠肾皮质切片或人红细胞中基本清除所有细胞内地高辛。在从红细胞中清除地高辛时，这些抗体能够逆转该药物对细胞钾转运的作用。本研究提供了直接证据，表明抗体能够在生理活性低分子量物质被哺乳动物细胞摄取后将其清除，从而逆转其生物学效应。地高辛特异性抗体的这种生物学特性表明，自身抗地高辛血清可能被证明对逆转地高辛毒性有用。抗体快速且基本定量地从红细胞中清除地高辛，并未伴随着钾流入立即恢复到正常水平。确定这一现象的机制不仅可能提供有关地高辛作用方式的有用信息，还可能提供有关人红细胞阳离子转运系统作用方式的有用信息。