Hirszel P, Lasrich M, Maher J F
J Lab Clin Med. 1979 Nov;94(5):747-54.
The effect of catecholamines on transport during peritoneal dialysis was studied in unanesthetized rabbits. Intravenous I-norepinephrine consistently decreased peritoneal clearances of urea and creatinine to 84% of control values or less but did not affect osmotically induced water flux. Comparable pressor doses of dopamine increased clearances of urea and creatinine to 145% of control values, whereas osmotic fluid flux increased only slightly. Dopamine also increased urea transport when administered intraperitoneally. The augmentation of solute transport by dopamine was unaffected by simultaneous administration of propranalol, was decreased by phentolamine, and was abolished by haloperidol. Dopamine may be preferable toI-norepinephrine when vasopressor therapy is required during peritoneal dialysis. The augmented transport with dopamine appears to depend on the action of dopamine receptors causing mesenteric vasodilation and in part on alpha-adrenergic receptors simultaneously increasing blood pressure while mesenteric blood flow is maintained.
在未麻醉的兔子身上研究了儿茶酚胺对腹膜透析期间转运的影响。静脉注射去甲肾上腺素持续将尿素和肌酐的腹膜清除率降低至对照值的84%或更低，但不影响渗透诱导的水通量。相当剂量的多巴胺增加了尿素和肌酐的清除率至对照值的145%，而渗透液通量仅略有增加。多巴胺腹腔内给药时也增加了尿素转运。多巴胺对溶质转运的增强作用不受同时给予普萘洛尔的影响，酚妥拉明使其降低，氟哌啶醇则将其消除。在腹膜透析期间需要血管升压治疗时，多巴胺可能比去甲肾上腺素更可取。多巴胺增强的转运似乎依赖于多巴胺受体引起肠系膜血管舒张的作用，部分还依赖于α-肾上腺素能受体在维持肠系膜血流的同时升高血压的作用。
