Hirszel P, Lasrich M, Maher J F
Trans Am Soc Artif Intern Organs. 1979;25:110-3. doi: 10.1097/00002480-197902500-00022.
In rabbits, intravenous vasopressor doses of dopamine augmented peritoneal clearances of creatinine and urea, suggesting increased mesenteric blood flow and possibly augmented permeability. Intraperitoneal dopamine also accelerated peritoneal transport of urea. Solute transport across the peritoneum was decreased by intravenous infusion of 1-norepinephrine. Intraperitoneal administration of the alpha-adrenergic antagonist phentolamine partially abolished the augmentation of peritoneal clearances induced by intravenous dopamine. The results suggest that in patients undergoing peritoneal dialysis who require vasopressor therapy, dopamine should be preferred to norepinephrine.
在兔体内，静脉注射升压剂量的多巴胺可增加肌酐和尿素的腹膜清除率，提示肠系膜血流量增加，且可能通透性增强。腹腔内注射多巴胺也可加速尿素的腹膜转运。静脉输注去甲肾上腺素可降低溶质跨腹膜的转运。腹腔内给予α-肾上腺素能拮抗剂酚妥拉明可部分消除静脉注射多巴胺引起的腹膜清除率增加。结果表明，在接受腹膜透析且需要血管升压药治疗的患者中，多巴胺应优于去甲肾上腺素。
