Maher J F, Cassetta M, Shea C, Hohnadel D C
Nephron. 1978;20(1):18-23. doi: 10.1159/000181191.
Since vasodilators can restore toward normal the decreased peritoneal clearances associated with vascular disease, the influence of aminophylline on peritoneal solute transport was studied in unanesthetized rabbits. Mean control creatinine clearance was 0.56 ml/kg/min and urea clearance 0.80 ml/kg/min. Neither intraperitoneal nor intravenous aminophylline increased peritoneal clearances, nor did the ratio creatinine clearance/urea clearance change from the control value, 0.70. Bidirectional flux of theophylline occurred at clearances of 0.70 ml/kg/min efflux and 0.64 ml/min influx. The removal rate of theophylline was 0.05% min, allowing therapeutic removal of excess aminophylline and warranting supplemental therapy during dialysis if therapeutic theophylline concentrations are required. As the intraperitoneal aminophylline was well tolerated, this route can be considered for therapeutic administration.
由于血管扩张剂可使与血管疾病相关的降低的腹膜清除率恢复正常，因此在未麻醉的兔子中研究了氨茶碱对腹膜溶质转运的影响。对照时肌酐清除率的平均值为0.56 ml/kg/分钟，尿素清除率为0.80 ml/kg/分钟。腹腔内或静脉注射氨茶碱均未增加腹膜清除率，肌酐清除率/尿素清除率的比值也未从对照值0.70改变。氨茶碱的双向通量在清除率为0.70 ml/kg/分钟（流出）和0.64 ml/分钟（流入）时出现。氨茶碱的清除率为0.05%/分钟，允许治疗性清除过量的氨茶碱，并且如果需要治疗性氨茶碱浓度，则在透析期间需要补充治疗。由于腹腔内注射氨茶碱耐受性良好，因此该途径可考虑用于治疗给药。
