人淋巴母细胞干扰素制剂的核糖核酸酶活性
Ribonuclease activity of preparations of human lymphoblastoid interferon.
作者信息
Karpetsky T P, Winchurch R A, Burman C J, Fantes K H
出版信息
J Gen Virol. 1979 Jul;44(1):241-4. doi: 10.1099/0022-1317-44-1-241.
PMID:501337
Abstract
Crude human lymphoblastoid interferon has less ribonuclease activity than equivalent primary leukocyte interferon and ribonuclease was eliminated when it was purified. The methods used differed from those that had failed to eliminate similar activity from leukocyte interferon. This result makes it unlikely that exogenous ribonuclease plays a major role in the antiviral action of interferon preparations.
摘要
粗制人淋巴母细胞干扰素的核糖核酸酶活性低于等量的原代白细胞干扰素，且在纯化时核糖核酸酶被去除。所采用的方法与那些未能从白细胞干扰素中去除类似活性的方法不同。这一结果使得外源性核糖核酸酶在干扰素制剂的抗病毒作用中不太可能起主要作用。
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