Abb J, Abb H, Deinhardt F
Immunopharmacology. 1982 Aug;4(4):303-10. doi: 10.1016/0162-3109(82)90051-0.
Retinoic acid (RA) suppressed the production of interferon (IFN) alpha and IFN gamma of human peripheral blood leukocytes in response to stimulation with lectin mitogens, bacterial products, synthetic polynucleotides, viruses, and tumor cell lines in vitro. Virus-induced secretion of IFN alpha of human lymphoblastoid cells was also inhibited. RA-mediated suppression was dose-dependent and required the near-concurrent addition of RA and inducers to human leukocyte cultures, thus suggesting that RA affects an early cellular function in the generation of IFN. Implications of these findings for the use of retinoids in the treatment of human malignancies are discussed.
维甲酸（RA）在体外可抑制人外周血白细胞在受到凝集素促细胞分裂剂、细菌产物、合成多核苷酸、病毒和肿瘤细胞系刺激时产生α干扰素（IFN）和γ干扰素。人淋巴母细胞系中病毒诱导的α干扰素分泌也受到抑制。RA介导的抑制作用呈剂量依赖性，且需要在人白细胞培养物中几乎同时添加RA和诱导剂，因此表明RA影响IFN产生过程中的早期细胞功能。文中讨论了这些发现对于使用类维生素A治疗人类恶性肿瘤的意义。
