Ruder H J, Loriaux L, Lipsett M B
J Clin Invest. 1972 Apr;51(4):1020-33. doi: 10.1172/JCI106862.
Since estrone sulfate (E(1)S) is present at high concentration in plasma, we have examined the parameters of the plasma estrone, estradiol, E(1)S system. The metabolic clearance rate of E(1)S was 157 liter/day (range 70-292) in men and women. Estimated plasma production rates of E(1)S were (mugrams per day): men, 77; women, early follicular phase, 95; women, early luteal phase, 182. The conversion of plasma estrone and estradiol to E(1)S was measured and from these data and the metabolic clearance rates of the estrogens, the transfer factors were rho(E) (1) (E) (1) (S) = 0.54 and rho(E) (2) (E) (1) (S) = 0.65. Using average production rates, all plasma E(1)S could be shown to be derived from plasma estrone and estradiol. The conversion of plasma E(1)S to plasma estrone and estradiol was studied. The calculated transfer factors were: rho(E) (1) (SE) (1) = 0.21, rho(E) (1) (SE) (2) = 0.014. Essentially, similar data were obtained when E(1)S was given by mouth to two subjects. WE CONCLUDE: (a) E(1)S is a major circulating plasma estrogen and has a long plasma half-life; (b) the large contributions of estrone and estradiol to plasma E(1)S are more than sufficient to account for all the circulating plasma E(1)S.
由于硫酸雌酮（E(1)S）在血浆中以高浓度存在，我们研究了血浆雌酮、雌二醇、E(1)S系统的参数。E(1)S在男性和女性中的代谢清除率为157升/天（范围70 - 292）。E(1)S的血浆生成率估计为（微克/天）：男性，77；女性，卵泡早期，95；女性，黄体早期，182。测量了血浆雌酮和雌二醇向E(1)S的转化，根据这些数据以及雌激素的代谢清除率，转移因子为rho(E)(1)(E)(1)(S)=0.54和rho(E)(2)(E)(1)(S)=0.65。使用平均生成率，所有血浆E(1)S都可显示源自血浆雌酮和雌二醇。研究了血浆E(1)S向血浆雌酮和雌二醇的转化。计算出的转移因子为：rho(E)(1)(SE)(1)=0.21，rho(E)(1)(SE)(2)=0.014。本质上，当给两名受试者口服E(1)S时获得了相似的数据。我们得出结论：(a) E(1)S是主要的循环血浆雌激素，且血浆半衰期长；(b) 雌酮和雌二醇对血浆E(1)S的大量贡献足以解释所有循环血浆E(1)S。
