Wright K, Collins D C, Preedy J R
J Clin Endocrinol Metab. 1978 Nov;47(5):1084-91. doi: 10.1210/jcem-47-5-1084.
Specific RIAs requiring ether extraction only were established for estrone and 17 beta-estradiol both in plasma and in urine from the nonpregnant female. These assays were used to measure the renal clearance rates of estrone and of 17 beta-estradiol in eight ambulatory women in the follicular and in the luteal phases of the menstrual cycle. The mean (+/-SE) for the renal clearance rate of estrone was 0.71 +/- 0.058 ml/min in the follicular phase and 1.26 +/- 0.35 ml/min in the luteal phase. The mean (+/-SE) renal clearance rate of 17 beta-estradiol was 0.44 +/- 0.055 ml/min in the follicular phase and 0.29 +/- 0.043 ml/min in the luteal phase. There was no significant difference in the renal clearance rates of either estrone or of 17 beta-estradiol between the follicular and luteal phases of the cycle. The renal clearances of estrone and 17 beta-estradiol were highly correlated (r = 0.84; P less than 0.01). The renal clearance rate of estrone was significantly greater than that of 17 beta-estradiol in both phases of the cycle (P less than 0.01).
仅需乙醚萃取的特定放射免疫分析法用于测定非孕女性血浆和尿液中的雌酮及17β-雌二醇。这些分析方法被用于测量8名处于月经周期卵泡期和黄体期的非卧床女性中雌酮及17β-雌二醇的肾脏清除率。雌酮肾脏清除率在卵泡期的均值（±标准误）为0.71±0.058毫升/分钟，在黄体期为1.26±0.35毫升/分钟。17β-雌二醇的平均（±标准误）肾脏清除率在卵泡期为0.44±0.055毫升/分钟，在黄体期为0.29±0.043毫升/分钟。在月经周期的卵泡期和黄体期之间，雌酮或17β-雌二醇的肾脏清除率均无显著差异。雌酮和17β-雌二醇的肾脏清除率高度相关（r = 0.84；P<0.01）。在月经周期的两个阶段，雌酮的肾脏清除率均显著高于17β-雌二醇（P<0.01）。
