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[促肾上腺皮质激素(ACTH)、α和β促黑素(MSH)以及β促脂素共同的寡肽片段的低钙血症、低磷血症、高脂血症和免疫原性活性的体内研究]

[In vivo study of the hypocalcemic, hypophosphoremic, hyperlipemic, and immunogenic activities of the oligopeptide fragment common to ACTH, alpha and beta MSH, and beta lipotropin].

作者信息

Drouhault R, Bethous C, Blanquet P

出版信息

C R Acad Hebd Seances Acad Sci D. 1975 May 12;280(18):2141-3.

PMID:50150
Abstract

The intravenous injection that was given to rabbits which consisted of 0,5 mg of a common heptapeptide to ACTH4-10, BETA MSH11-17 hormones, and to beta lipotropic47-53 hormone (beta LPH47-53) was followed at the end of an hour by an augmentation of 70% of total lipids, and at the end of two hours by a lowering of calcemia (around 27%) and of phosphoremia (20%). The injection of a tetrapeptide corresponding to only ACTH7-10 bound to a nitrobenzylhydralamin and in presence of a Freund adjuvants has provoked the formation of corresponding antibodies.

摘要

给兔子静脉注射由0.5毫克常见的七肽组成的物质,该七肽包含促肾上腺皮质激素4 - 10、β-促黑素11 - 17激素以及β-促脂素47 - 53激素(β-LPH47 - 53)。一小时后,总脂质增加了70%,两小时后,血钙降低(约27%),血磷降低(20%)。注射仅对应促肾上腺皮质激素7 - 10且与硝基苄基肼结合并存在弗氏佐剂的四肽,引发了相应抗体的形成。

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