哌替啶、东莨菪碱和地西泮对成年人的顺行性遗忘作用。
Anterograde amnesic effects of pethidine, hyoscine and diazepam in adults.
作者信息
Dundee J W, Pandit S K
出版信息
Br J Pharmacol. 1972 Jan;44(1):140-4. doi: 10.1111/j.1476-5381.1972.tb07245.x.
Abstract
- The intravenous administration of 5 and 10 mg of diazepam caused anterograde amnesia in 50 and 90% of adults, the peak effect occurring in 2-3 min and action persisting for 20-30 minutes.2. Hyoscine (0.4 and 0.6 mg) caused amnesia in 35 and 50% of patients with peak effect not occurring until 50-80 min after injection and action persisting for at least 120 minutes.3. With neither drug was there any relationship between the incidence of amnesia and the degree of drowsiness.4. Amnesia was not observed after saline or after 50 mg pethidine.5. On questioning 6 h after a short operation many patients had no memory of an object which they clearly recognized and described 1 h after surgery.
摘要
- 静脉注射5毫克和10毫克地西泮会使50%和90%的成年人出现顺行性遗忘，高峰效应出现在2至3分钟，作用持续20至30分钟。2. 东莨菪碱（0.4毫克和0.6毫克）会使35%和50%的患者出现遗忘，高峰效应直到注射后50至80分钟才出现，作用持续至少120分钟。3. 两种药物的遗忘发生率与嗜睡程度均无关联。4. 注射生理盐水或50毫克哌替啶后未观察到遗忘现象。5. 在一次小手术后6小时进行询问时，许多患者对一个在手术后1小时他们能清楚认出并描述的物体没有记忆。
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