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小檗碱在毒素诱导的实验性霍乱中的作用

Berberine in toxin-induced experimental cholera.

作者信息

Dutta N K, Marker P H, Rao N R

出版信息

Br J Pharmacol. 1972 Jan;44(1):153-9. doi: 10.1111/j.1476-5381.1972.tb07247.x.

DOI:10.1111/j.1476-5381.1972.tb07247.x
PMID:5015035
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1665699/
Abstract
  1. Oral administration of berberine to infant rabbits 18-24 h before the intraintestinal administration of choleragenic toxins, arrests diarrhoea or significantly prolongs the survival time.2. The use of berberine in the treatment of clinical cholera is further justified.3. Berberine is an antidiarrhoeal drug and the host tissues play a major part in the control of diarrhoeal symptoms.
摘要
  1. 在向幼兔肠道内施用致霍乱毒素前18 - 24小时口服黄连素，可抑制腹泻或显著延长存活时间。2. 黄连素用于临床霍乱治疗的合理性进一步得到证实。3. 黄连素是一种止泻药，宿主组织在腹泻症状的控制中起主要作用。

相似文献

1
Berberine in toxin-induced experimental cholera.小檗碱在毒素诱导的实验性霍乱中的作用
Br J Pharmacol. 1972 Jan;44(1):153-9. doi: 10.1111/j.1476-5381.1972.tb07247.x.
2
Clinical trial of berberine in acute watery diarrhoea.黄连素治疗急性水样腹泻的临床试验
Br Med J (Clin Res Ed). 1985 Dec 7;291(6509):1601-5. doi: 10.1136/bmj.291.6509.1601.
3
Anti-inflammatory effect of berberine in rats injected locally with cholera toxin.黄连素对局部注射霍乱毒素大鼠的抗炎作用。
Indian J Med Res. 1977 Jan;65(1):133-41.
4
Randomized controlled trial of berberine sulfate therapy for diarrhea due to enterotoxigenic Escherichia coli and Vibrio cholerae.硫酸小檗碱治疗产肠毒素大肠杆菌和霍乱弧菌所致腹泻的随机对照试验
J Infect Dis. 1987 May;155(5):979-84. doi: 10.1093/infdis/155.5.979.
5
Possible mechanism of antidiarrhoeal effect of berberine.黄连素止泻作用的可能机制。
Indian J Med Res. 1979 Aug;70:233-41.
6
Antagonism of cholera toxin by berberine in the gastrointestinal tract of adult rats.黄连素对成年大鼠胃肠道中霍乱毒素的拮抗作用。
Indian J Med Res. 1977 Mar;65(3):305-13.
7
Mechanism and treatment of diarrhoea due to Vibrio cholerae and Escherichia coli: roles of drugs and prostaglandins.霍乱弧菌和大肠杆菌所致腹泻的机制与治疗：药物和前列腺素的作用
Dan Med Bull. 1996 Apr;43(2):173-85.
8
Clinical trial of high-dose berberine and tetracycline in cholera.高剂量黄连素和四环素治疗霍乱的临床试验
J Diarrhoeal Dis Res. 1987 Sep;5(3):184-7.
9
Separation of type 2 toxins of Vibrio cholerae.霍乱弧菌2型毒素的分离
Science. 1969 Aug 22;165(3895):808-9. doi: 10.1126/science.165.3895.808.
10
Berberine and chloramphenicol in the treatment of cholera and severe diarrhoea.黄连素与氯霉素治疗霍乱及严重腹泻
J Indian Med Assoc. 1967 Jan 1;48(1):1-11.

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Crystal structure of an integron gene cassette-associated protein from Vibrio cholerae identifies a cationic drug-binding module.霍乱弧菌整合子基因盒相关蛋白的晶体结构鉴定出一种阳离子药物结合模块。
PLoS One. 2011 Mar 3;6(3):e16934. doi: 10.1371/journal.pone.0016934.
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Berberine inhibition of electrogenic ion transport in rat colon.小檗碱对大鼠结肠电生性离子转运的抑制作用。
Br J Pharmacol. 1995 Nov;116(6):2667-72. doi: 10.1111/j.1476-5381.1995.tb17224.x.
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Antidiarrheal therapy. Prospects for new agents.止泻疗法。新型药物的前景。
Dig Dis Sci. 1987 Feb;32(2):195-205. doi: 10.1007/BF01297108.

本文引用的文献

1
EXPERIMENTAL CHOLERA PRODUCED BY TOXIN PREPARED BY ULTRASONIC DISINTEGRATION OF VIBRIO COMMA.由霍乱弧菌超声破碎制备的毒素所引发的实验性霍乱
J Bacteriol. 1963 Feb;85(2):497-8. doi: 10.1128/jb.85.2.497-498.1963.
2
PATHOGENESIS EXPERIMENTAL CHOLERA IN INFANT RABBITS. I. OBSERVATIONS ON THE INTRAINTESTINAL INFECTION AND EXPERIMENTAL CHOLERA PRODUCED WITH CELL-FREE PRODUCTS.幼兔实验性霍乱的发病机制。I. 关于无细胞产物引起的肠道内感染及实验性霍乱的观察
J Infect Dis. 1964 Jun;114:203-16. doi: 10.1093/infdis/114.3.203.
3
Berberine and chloramphenicol in the treatment of cholera and severe diarrhoea.黄连素与氯霉素治疗霍乱及严重腹泻
J Indian Med Assoc. 1967 Jan 1;48(1):1-11.
4
Effect of berberine alkaloid on cholera Vibro and its endotoxin.小檗碱生物碱对霍乱弧菌及其内毒素的作用。
J Egypt Med Assoc. 1966;49(8):554-9.
5
Vibriostatic action of berberine.小檗碱的抑菌作用。
Indian J Pathol Bacteriol. 1967 Oct;10(4):389-91.
6
Effect of berberine on the fatty acid composition of Vibrio cholerae and Vibrio cholerae biotype eltor.黄连素对霍乱弧菌和埃尔托生物型霍乱弧菌脂肪酸组成的影响。
Indian J Med Res. 1970 Nov;58(11):1523-7.
7
Mechanism of action of berberine on Vibrio cholerae and vibrio cholerae biotype eltor.黄连素对霍乱弧菌及埃尔托生物型霍乱弧菌的作用机制
Indian J Med Res. 1970 Nov;58(11):1510-22.
8
Absorption, distribution and excretion of berberine.小檗碱的吸收、分布与排泄。
Indian J Med Res. 1969 Nov;57(11):2128-31.
9
Berberine sulfate: antimicrobial activity, bioassay, and mode of action.硫酸小檗碱：抗菌活性、生物测定及作用方式。
Can J Microbiol. 1969 Sep;15(9):1067-76. doi: 10.1139/m69-190.
10
Berberine in the treatment of diarrhoea of infancy and childhood.黄连素治疗婴幼儿腹泻
J Indian Med Assoc. 1970 Jan 1;54(1):22-4.