氨基氧乙酸在鸡体内的药理特性。
Pharmacological properties of amino-oxyacetic acid in the chicken.
作者信息
Osuide G
出版信息
Br J Pharmacol. 1972 Jan;44(1):31-44. doi: 10.1111/j.1476-5381.1972.tb07235.x.
Abstract
- The effects of amino-oxyacetic acid (AOAA) on the central nervous system and on skeletal muscle have been examined in the chicken.2. AOAA had both anticonvulsant and convulsant effects, depending on the dose, as in other species.3. The convulsant effect, accompanied by EEG spiking, decreased rapidly with increase in age of young chicks.4. The convulsant effect was exerted primarily through supraspinal centres.5. Of control depressants tested, only troxidone and small doses of AOAA afforded significant protection against AOAA seizures.
摘要
已在鸡身上研究了氨氧基乙酸（AOAA）对中枢神经系统和骨骼肌的作用。
与其他物种一样，AOAA根据剂量不同，既有抗惊厥作用，也有惊厥作用。
伴随着脑电图尖峰的惊厥作用，随着幼雏年龄的增加而迅速减弱。
惊厥作用主要通过脊髓上中枢发挥。
在 tested 的对照抑制剂中，只有三甲双酮和小剂量的AOAA对AOAA引起的癫痫发作有显著的保护作用。 （注：这里“tested”原文表述有误，推测可能是“tested”，翻译时做了相应调整）
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