Meyer M C, Raghow G
J Pharm Sci. 1979 Sep;68(9):1127-30. doi: 10.1002/jps.2600680918.
A high-pressure liquid chromatographic procedure was developed for griseofulvin assay in human plasma. The method utilized warfarin as an internal standard and easily quantitated griseofulvin plasma levels as low as 0.10 micrograms/ml. The method was compared to two fluorometric assay methods and was more specific for griseofulvin. Assay of 6-demethylgriseofulvin isolated from human urine demonstrated that this material was not responsible for the interferences apparent in the fluorometric procedures.
已开发出一种用于测定人血浆中灰黄霉素的高压液相色谱法。该方法使用华法林作为内标，可轻松定量低至0.10微克/毫升的灰黄霉素血浆水平。将该方法与两种荧光测定法进行了比较，它对灰黄霉素更具特异性。对从人尿中分离出的6-去甲基灰黄霉素的测定表明，这种物质并非荧光测定法中明显干扰的原因。
