Sassard J, Bernard N, Legheand J, Cuisinaud G, Traeger J
J Pharm Sci. 1979 Sep;68(9):1190-1. doi: 10.1002/jps.2600680939.
The pharmacokinetics of two pyridinol carbamate formulations were studied after a single oral administration in 10 healthy volunteers. An open one-compartment model described the evolution of plasma concentrations as a function of time. Pyridinol carbamate was rapidly absorbed (mean lag time from 0.36 to 0.38 hr). Its elimination half-life ranged from 3.3 to 7.9 hr. The two formulations were bioequivalent.
在10名健康志愿者单次口服给药后，研究了两种吡啶醇氨基甲酸酯制剂的药代动力学。一个开放的一室模型描述了血浆浓度随时间的变化。吡啶醇氨基甲酸酯吸收迅速（平均滞后时间为0.36至0.38小时）。其消除半衰期为3.3至7.9小时。这两种制剂具有生物等效性。
