Sadowski B, Wauquier A, Jageneau A, Janssen P A
J Physiol (Paris). 1979;75(3):255-67.
In dogs pressing a lever for a brain-stimulation reward, arterial blood pressure (ABP) was elevated for 20 out of 24 sites tested, but this effect was usually conspicuous only at twice the threshold current sustaining stable performance. Hypertension was seen only in one ventral tegmental and two hypothalamic sites. In three anterior placements the ABP and heart rate (HR) increased more upon a fixed ratio than on continuous reinforcement. In most sites, self-stimulation was accompanied by cardiac acceleration; however, in some placements the HR was similar to or even less than control values. Continuous stimulation (5-10 sec) at one nucleus accumbens and four hypothalamic sites by the experimenter was aversive and produced a clearcut pressor response. The cardiovascular changes seem to depend on a spread of current to brain centres controlling circulatory functions and also, to some extent, on the animal's motor activity. The results contradict the claim that a causal relationship exists between the autonomic concomitants of self-stimulation and the intrinsic nature of the brain-stimulation reward.
在通过按压杠杆以获得脑刺激奖励的犬类实验中，在测试的24个位点中有20个位点的动脉血压（ABP）升高，但这种效应通常仅在维持稳定表现的阈值电流的两倍时才明显。仅在一个腹侧被盖区和两个下丘脑位点观察到高血压。在三个前部植入位点，固定比率强化时的ABP和心率（HR）比连续强化时升高得更多。在大多数位点，自我刺激伴随着心率加快；然而，在一些植入位点，HR与对照值相似甚至更低。实验者在一个伏隔核和四个下丘脑位点进行的持续刺激（5 - 10秒）是厌恶的，并产生明显的升压反应。心血管变化似乎取决于电流扩散到控制循环功能的脑中心，并且在某种程度上也取决于动物的运动活动。这些结果与自我刺激的自主伴随现象与脑刺激奖励的内在性质之间存在因果关系这一说法相矛盾。
