Rotenberg D, Lawson V G, van Nostrand A W
J Otolaryngol. 1979 Oct;8(5):401-10.
Ectopic thyroid tissue within the submucosa of the trachea is a rare cause of upper airway obstruction. Most case reports in the literature record examples of intratracheal goiter with only occasional reports of neoplasms arising from such thyroid rests. This report describes a young female patient with a malignant tumor, thought to be primary in the trachea, treated first by radiotherapy and eventually successfully surgically excised. The surgical resection required total thyroidectomy with partial laryngectomy and major tracheal resection, and provided an excellent functional result. The clinical history, laboratory findings and histologic sections strongly suggest that this tumor arose within the tracheal submucosa from ectopic thyroid tissue. In a series of 250 serially sectioned larynges, such ectopic thyroid tissue has been identified in only two patients.
气管黏膜下层的异位甲状腺组织是上呼吸道梗阻的罕见原因。文献中的大多数病例报告记录的是气管内甲状腺肿的例子，仅有偶尔关于源于此类甲状腺残余组织的肿瘤的报告。本报告描述了一名年轻女性患者，患有被认为原发于气管的恶性肿瘤，首先接受了放射治疗，最终成功进行了手术切除。手术切除需要进行全甲状腺切除术、部分喉切除术和气管大部切除术，并取得了良好的功能效果。临床病史、实验室检查结果和组织学切片强烈提示，该肿瘤起源于气管黏膜下层的异位甲状腺组织。在一系列250例连续切片的喉部标本中，仅在两名患者中发现了这种异位甲状腺组织。
