Ueda E, Hayashi Y, Kawabe T, Kato I, Yoshida N, Kokubu T
Jpn Circ J. 1979 Sep;43(9):866-9. doi: 10.1253/jcj.43.866.
Reserpine was administered in purpose to determine the "Noradrenaline store" in sympathetic nerve endings. The marked increase of urinary noradrenaline excretion was observed by reserpine 0.4 mg/day administration. Total amount of noradrenaline in urine for first three days of 0.4 mg/day of reserpine administration was considered as a good indicators of "Noradrenaline store". There was no difference of "Noradrenaline store" between normal and hypertensive subjects. The increase % of urinary noradrenaline was higher in labile hypertension than in established hypertension as well as in normal subjects. Though the relationship between "Noradrenaline store" or the increase % of noradrenaline and sympathetic nerve activity was not clear, it is suspected that the releasable noradrenaline in sympathetic nerve granule was higher in labile hypertension than in established hypertension or normal subjects.
给予利血平的目的是测定交感神经末梢中的“去甲肾上腺素储备”。通过每天给予0.4毫克利血平，观察到尿去甲肾上腺素排泄量显著增加。利血平每日0.4毫克给药的前三天尿液中去甲肾上腺素的总量被视为“去甲肾上腺素储备”的良好指标。正常人和高血压患者之间的“去甲肾上腺素储备”没有差异。与持续性高血压患者以及正常受试者相比，波动性高血压患者尿去甲肾上腺素的增加百分比更高。尽管“去甲肾上腺素储备”或去甲肾上腺素增加百分比与交感神经活动之间的关系尚不清楚，但怀疑波动性高血压患者交感神经颗粒中可释放的去甲肾上腺素高于持续性高血压患者或正常受试者。
