Edelson P J
Calif Med. 1972 Apr;116(4):19-24.
A defective host response may be responsible for recurring infections in certain children. Recognition of these defects may be important both therapeutically for the patient and for genetic counseling for the family. Family history, age of onset of illness and type of infecting agents may all point to one or another defect in host resistance. An initial evaluation for suspected immunologic disease may be rapidly accomplished and should include absolute neutrophil and lymphocyte counts, chest X-ray for a thymic shadow, Schick test for functional IgG antibodies and isohemagglutinin titers for functional IgM antibodies. Although serum protein electrophoresis is unreliable for diagnosis of most disorders of circulating antibodies, quantitation of the IgG, IgA and IgM antibody classes is generally available. More extensive studies may be carried out to further define defects in the cell-mediated immune system, in the various complement components, or in the ingestion and killing of bacteria by neutrophils.
宿主反应缺陷可能是某些儿童反复感染的原因。识别这些缺陷对于患者的治疗以及家庭的遗传咨询都可能很重要。家族史、发病年龄和感染病原体类型都可能指向宿主抵抗力的一种或另一种缺陷。对疑似免疫疾病的初步评估可以迅速完成，应包括绝对中性粒细胞和淋巴细胞计数、胸部X光检查胸腺阴影、检测功能性IgG抗体的锡克试验以及检测功能性IgM抗体的同种血凝素滴度。虽然血清蛋白电泳对于大多数循环抗体疾病的诊断不可靠，但通常可以对IgG、IgA和IgM抗体类别进行定量。可以进行更广泛的研究以进一步确定细胞介导免疫系统、各种补体成分或中性粒细胞对细菌的吞噬和杀伤方面的缺陷。
