Strahilevitz M, Fleischman J B, Fischer G W, Harris R, Narasimhachari N
Am J Psychiatry. 1976 Jul;133(7):772-7. doi: 10.1176/ajp.133.7.772.
In a study of 19 schizophrenic patients, 7 nonschizophrenic patients, and 31 controls, the authors found significantly higher mean serum levels of 1) immunoglobulin A in schizophrenic women then in control women and in schizophrenic blacks than in either schizophrenic whites or black controls. 2) immunoglobulin D in schizophrenic blacks than in schizophrenic whites, 3) immunoglobulin M in controls than in nonschizophrenic patients, and 4) immunoglobulin G (IgG) in schizophrenics whose urine was positive for phenothiazines than in schizophrenics whose urine was negative for phenothiazines. High serum levels of IgG were associated with no or mild hallucinations and low levels with moderate or severe hallucinations. Black female patients had significantly more severe hallucinaions than white female patients. The authors discuss the possible implications of these findings.
在一项针对19名精神分裂症患者、7名非精神分裂症患者和31名对照者的研究中，作者发现以下几种免疫球蛋白的平均血清水平显著更高：1）精神分裂症女性患者的免疫球蛋白A高于对照女性，且精神分裂症黑人患者的免疫球蛋白A高于精神分裂症白人患者或黑人对照者。2）精神分裂症黑人患者的免疫球蛋白D高于精神分裂症白人患者。3）对照者的免疫球蛋白M高于非精神分裂症患者。4）尿液中吩噻嗪呈阳性的精神分裂症患者的免疫球蛋白G（IgG）高于尿液中吩噻嗪呈阴性的精神分裂症患者。高血清水平的IgG与无幻觉或轻度幻觉相关，低水平则与中度或重度幻觉相关。黑人女性患者的幻觉比白人女性患者严重得多。作者讨论了这些发现可能带来的影响。
