Rao S, Rose M E, Rosenberg A, Sproule B J
Can Med Assoc J. 1972 May 20;106(10):1081-4.
Administration of ultrasonically nebulized mist to 17 patients with obstructive lung disease resulted in a temporary deterioration of mechanical lung function with decreases in vital capacity (VC), forced expired volume in one second expressed as a percentage of VC (FEV(1)%), and compliance and with increased inspiratory and expiratory airway resistance. Despite hyperventilation there was an associated decrease in arterial oxygen tension. Although concomitant administration of a bronchodilator afforded protection against the bronchospastic reaction, blood gas derangements were still provoked.
对17例阻塞性肺病患者进行超声雾化治疗后，患者肺功能出现暂时恶化，表现为肺活量（VC）、一秒用力呼气容积占肺活量百分比（FEV(1)%）和肺顺应性下降，吸气和呼气气道阻力增加。尽管患者出现过度通气，但动脉血氧分压仍下降。虽然同时给予支气管扩张剂可预防支气管痉挛反应，但仍会引发血气紊乱。
