Drachman D B, Witzke F
Science. 1972 May 5;176(4034):514-6. doi: 10.1126/science.176.4034.514.
Denervation of skeletal muscle results in a spread of acetylcholine sensitivity over the entire surface membrane. Electrical stimulation, programmed to mimic the normal activity pattern, was applied continuously to the denervated rat diaphragm in vivo. After 4 days, the acetylcholine sensitivity was far less in the stimulated diaphragms than in denervated controls. Muscle activity may account for "neurotrophic" regulation of the acetylcholine sensitivity.
骨骼肌去神经支配会导致乙酰胆碱敏感性在整个表面膜上扩散。在体内对去神经支配的大鼠膈肌持续施加按程序设定以模拟正常活动模式的电刺激。4天后，受刺激的膈肌中的乙酰胆碱敏感性远低于去神经支配的对照膈肌。肌肉活动可能是乙酰胆碱敏感性“神经营养”调节的原因。
