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细胞培养中肌肉活动对肌肉乙酰胆碱敏感性的调节。

Regulation of muscle acetylcholine sensitivity by muscle activity in cell culture.

作者信息

Cohen S A, Fischbach G D

出版信息

Science. 1973 Jul 6;181(4094):76-8. doi: 10.1126/science.181.4094.76.

DOI:10.1126/science.181.4094.76
PMID:4736607
Abstract

Muscle in tissue culture provides a good system for studying longterm changes in surface membrane acetylcholine sensitivity. Muscle fibers stimulated intermittently over prolonged periods are less sensitive to iontophoretically applied acetylcholine and bind less (125)I-labeled alpha-bungarotoxin than inactive fibers.

摘要

组织培养中的肌肉为研究表面膜乙酰胆碱敏感性的长期变化提供了一个良好的系统。在较长时间内间歇性刺激的肌肉纤维对离子电渗法施加的乙酰胆碱敏感性较低，并且与未活化的纤维相比，结合的（125）I标记的α-银环蛇毒素更少。

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