佐剂处理的豚鼠离体平滑肌制剂中的过敏反应性超敏反应。
Anaphylactic hypersensitivity in isolated smooth muscle preparations from adjuvant-treated guinea-pigs.
作者信息
Skeldon N, Hicks R
出版信息
Immunology. 1972 Jun;22(6):1065-73.
Anaphylactic hypersensitivity of isolated guinea-pig ileum preparations has been evaluated by investigation of antigen-dose/response relationships, . The influence of Freund's adjuvants on active sensitization has been investigated. In contrast to the inhibitory influence previously observed , the degree of hypersensitivity of isolated tissues was potentiated by the adjuvants. It is thought that high circulating titres of antibody exerted a protective or neutralizing effect in relation to challenging doses of antigen. Isolated tissues were freed from this influence. Tissues sensitized with the aid of Freund's complete adjuvant (FCA) revealed the influence of other inhibitory mechanisms, due probably to interaction of various antibody types.
通过研究抗原剂量/反应关系，对豚鼠离体回肠制剂的过敏性超敏反应进行了评估。研究了弗氏佐剂对主动致敏的影响。与先前观察到的抑制作用相反，佐剂增强了离体组织的超敏程度。据认为，高循环抗体滴度对激发剂量的抗原有保护或中和作用。离体组织不受这种影响。借助弗氏完全佐剂（FCA）致敏的组织显示出其他抑制机制的影响，这可能是由于各种抗体类型之间的相互作用所致。
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