混合淋巴细胞培养中发生反应并刺激反应的淋巴细胞的胸腺起源——大鼠研究
Thymus origin of lymphocytes reacting and stimulating reaction in mixed lymphocyte cultures--studies in the rat.
作者信息
Maclaurin B P
出版信息
Clin Exp Immunol. 1972 Apr;10(4):649-59.
Abstract
Mixed lymphocyte cultures between pairs of allogeneic cell suspensions from rat thymus of one strain versus thymus, lymph node, spleen or bone marrow from a histo-incompatible strain, have shown a decreasing gradient of stimulation capacity. After complete neonatal thymectomy 6 weeks previously, lymph-node lymphocytes are shown to have diminished or absent capacity to stimulate allogeneic rat thymocytes in mixed culture. It it concluded that thymus-derived lymphocytes appear to be required both for stimulation as well as for reaction in the mixed lymphocyte test.
摘要
将来自一个品系大鼠胸腺的同种异体细胞悬液与组织不相容品系的胸腺、淋巴结、脾脏或骨髓的同种异体细胞悬液进行混合淋巴细胞培养，结果显示刺激能力呈递减梯度。在6周前进行完全新生期胸腺切除术后，混合培养中淋巴结淋巴细胞刺激同种异体大鼠胸腺细胞的能力减弱或丧失。由此得出结论，在混合淋巴细胞试验中，似乎既需要胸腺来源的淋巴细胞进行刺激，也需要其进行反应。
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