2型和13型豚鼠中髓鞘碱性蛋白的免疫活性
Immunologic activity of myelin basic protein in strain 2 and strain 13 guinea pigs.
作者信息
Kies M W, Driscoll B F, Lisak R P, Alvord E C
出版信息
J Immunol. 1975 Jul;115(1):75-9.
The resistance of Strain 2 guinea pigs to experimental allergic encephalomyelitis (EAE) induced by inoculation with whole CNS tissue in complete Freund's adjuvant (CFA) has been confirmed. The resistance is even more pronounced when myelin basic protein (BP) is used in attempts to induce EAE. Strain 2 guinea pigs are also resistant to an immunization schedule (multiple injections with BP in IFA followed by a single injection of BP in CFA) known to induce significant levels of antibody in susceptible strains. The poor response of Strain 2 guinea pigs to BP is not the result of lack of specific B cells--antibody equivalent to that produced by Strain 13 animals is obtained when the inoculum contains 0.5 mg BP and 2.5 mycobacteria.
已证实，2系豚鼠对接种于完全弗氏佐剂（CFA）中的全中枢神经系统组织诱导的实验性变应性脑脊髓炎（EAE）具有抵抗力。当使用髓磷脂碱性蛋白（BP）诱导EAE时，这种抵抗力更为明显。2系豚鼠对已知能在易感品系中诱导产生高水平抗体的免疫程序（在不完全弗氏佐剂中多次注射BP，随后在CFA中单次注射BP）也具有抵抗力。2系豚鼠对BP反应不佳并非缺乏特异性B细胞所致——当接种物含有0.5毫克BP和2.5个分枝杆菌时，可获得与13系动物产生的抗体相当的抗体。
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