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复发缓解型多发性硬化症中髓鞘碱性蛋白的循环抗体？一项采用放射免疫分析法的比较组和序贯研究。

Circulating antibody to myelin basic protein in relapsing-remitting multiple sclerosis? A comparative group and sequential study by radioimmunoassay.

作者信息

Biggins J A, Taylor A, Caspary E A

出版信息

J Neurol Neurosurg Psychiatry. 1978 Dec;41(12):1131-4. doi: 10.1136/jnnp.41.12.1131.

DOI:10.1136/jnnp.41.12.1131
PMID:83354
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC493243/
Abstract

Sera from multiple sclerosis patients with relapsing-remitting disease and normal subjects were tested for antibody to myelin basic protein by a sensitive radioimmunoassay. The results showed a marginally decreased titre in multiple sclerosis superimposed on a seasonal variation. There was no correlation with the clinical state of the patients. Results are discussed briefly in relation to humoral antibody function in multiple sclerosis and experimental autoimmune encephalitis.

摘要

采用灵敏的放射免疫分析法对复发缓解型多发性硬化症患者及正常受试者的血清进行髓鞘碱性蛋白抗体检测。结果显示，在季节性变化的基础上，多发性硬化症患者的抗体滴度略有下降。这与患者的临床状态无关。本文简要讨论了这些结果与多发性硬化症及实验性自身免疫性脑脊髓炎中体液抗体功能的关系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0388/493243/0c7dbf0302e0/jnnpsyc00150-0076-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0388/493243/0c7dbf0302e0/jnnpsyc00150-0076-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0388/493243/0c7dbf0302e0/jnnpsyc00150-0076-a.jpg

相似文献

1
Circulating antibody to myelin basic protein in relapsing-remitting multiple sclerosis? A comparative group and sequential study by radioimmunoassay.复发缓解型多发性硬化症中髓鞘碱性蛋白的循环抗体？一项采用放射免疫分析法的比较组和序贯研究。
J Neurol Neurosurg Psychiatry. 1978 Dec;41(12):1131-4. doi: 10.1136/jnnp.41.12.1131.
2
Failure to detect antibodies to myelin basic protein or peptic fragments of myelin basic protein in CSF of patients with MS.未能在多发性硬化症患者的脑脊液中检测到针对髓鞘碱性蛋白或髓鞘碱性蛋白消化片段的抗体。
Neurology. 1983 Jan;33(1):24-8. doi: 10.1212/wnl.33.1.24.
3
Antibody to myelin basic protein in extracts of multiple sclerosis brain.多发性硬化症脑提取物中的髓鞘碱性蛋白抗体。
Immunology. 1981 Jul;43(3):447-57.
4
Endogenous myelin basic protein-serum factors (MBP-SFs) and anti-MBP antibodies in humans. Occurrence in sera of clinically well subjects and patients with multiple sclerosis.人体内源性髓鞘碱性蛋白-血清因子（MBP-SFs）和抗MBP抗体。在临床健康受试者和多发性硬化症患者血清中的出现情况。
J Neurol Sci. 1981 Oct;52(1):37-51. doi: 10.1016/0022-510x(81)90132-5.
5
Myelin basic protein: a component of circulating immune complexes in multiple sclerosis.髓鞘碱性蛋白：多发性硬化症中循环免疫复合物的一个组成部分。
Can J Neurol Sci. 1983 Nov;10(4):239-43. doi: 10.1017/s0317167100045078.
6
Are anti-brain antibodies in multiple sclerosis directed to myelin basic protein? Studies employing the Shiverer mouse mutant.多发性硬化症中的抗脑抗体是否针对髓鞘碱性蛋白？利用颤抖小鼠突变体开展的研究。
Acta Neurol Scand. 1986 Mar;73(3):247-52. doi: 10.1111/j.1600-0404.1986.tb03270.x.
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Antibodies to myelin basic protein in multiple sclerosis.多发性硬化症中针对髓鞘碱性蛋白的抗体。
Neurology. 1985 Jan;35(1):139-40. doi: 10.1212/wnl.35.1.139-b.
8
Components in multiple sclerosis cerebrospinal fluid that are detected by radioimmunoassay for myelin basic protein.通过髓鞘碱性蛋白放射免疫测定法在多发性硬化症脑脊液中检测到的成分。
Proc Natl Acad Sci U S A. 1978 Apr;75(4):1976-8. doi: 10.1073/pnas.75.4.1976.
9
Serum and cerebrospinal fluid antibodies against myelin basic protein and their IgG subclass distribution in multiple sclerosis.多发性硬化症患者血清和脑脊液中抗髓鞘碱性蛋白抗体及其IgG亚类分布
J Neurol Neurosurg Psychiatry. 1986 Sep;49(9):1066-70. doi: 10.1136/jnnp.49.9.1066.
10
Cerebrospinal fluid analysis differentiates between relapsing-remitting and secondary progressive multiple sclerosis.脑脊液分析可区分复发缓解型多发性硬化症和继发进展型多发性硬化症。
J Neurol Neurosurg Psychiatry. 1997 Oct;63(4):446-51. doi: 10.1136/jnnp.63.4.446.

本文引用的文献

1
CHRONIC DISSEMINATED ALLERGIC ENCEPHALOMYELITIS IN GUINEA PIGS.豚鼠慢性播散性变应性脑脊髓炎
Ann N Y Acad Sci. 1965 Mar 31;122:227-41. doi: 10.1111/j.1749-6632.1965.tb20206.x.
2
Antibody studies in rabbit encephalomyelitis induced by a water-soluble protein fraction of rabbit cord.兔脊髓水溶性蛋白组分诱导的兔脑脊髓炎中的抗体研究。
J Exp Med. 1962 Dec 1;116(6):807-25. doi: 10.1084/jem.116.6.807.
3
Suppression of allergic encephalomyelitis in rats by means of antibrain serum.通过抗脑血清抑制大鼠过敏性脑脊髓炎。
J Exp Med. 1963 May 1;117(5):755-74. doi: 10.1084/jem.117.5.755.
4
Search for anti-encephalitogen antibody in human demyelinative diseases.在人类脱髓鞘疾病中寻找抗脑髓炎原抗体。
Neurology. 1968 Jan;18(1 Pt 2):122-8. doi: 10.1212/wnl.18.1_part_2.122.
5
Binding of 125 I myelin basic protein by serum and cerebrospinal fluid.血清和脑脊液对¹²⁵I髓鞘碱性蛋白的结合
Clin Exp Immunol. 1972 Aug;11(4):595-603.
6
Multiple sclerosis: immunologic aspects.多发性硬化症：免疫学方面。
Ann Clin Lab Sci. 1975 Sep-Oct;5(5):324-9.
7
Chronic relapsing experimental allergic encephalomyelitis: an experimental model of multiple sclerosis.慢性复发性实验性变应性脑脊髓炎：一种多发性硬化症的实验模型。
Ann Neurol. 1977 Feb;1(2):144-8. doi: 10.1002/ana.410010207.
8
Studies on demyelination by activated lymphocytes in the rabbit eye. II. Antibody-dependent cell-mediated demyelination.兔眼内活化淋巴细胞所致脱髓鞘研究。II. 抗体依赖性细胞介导的脱髓鞘
J Immunol. 1977 Jun;118(6):2103-10.
9
Humoral factors involved in immune processes in multiple sclerosis and allergic encephalomyelitis.多发性硬化症和过敏性脑脊髓炎免疫过程中涉及的体液因素。
Br Med Bull. 1977 Jan;33(1):50-3. doi: 10.1093/oxfordjournals.bmb.a071396.
10
A comparison of the encephalitogenic activities of human myelin basic protein and the synthetic peptide determinant comprising residues 114-122.人髓鞘碱性蛋白与包含第114 - 122位残基的合成肽决定簇的致脑炎性活性比较。
J Neurochem. 1975 Nov;25(5):711-3. doi: 10.1111/j.1471-4159.1975.tb04393.x.