Mouawad E
Ann Anesthesiol Fr. 1975 Dec;16(9):721-4.
In neuro-anaesthesia, anaesthetic agents must be in accordance with certain criteria necessary to the preservation of the integrity of the brain. Therefore it was in such a perspective that we re-appraised the effects of enflurane upon cortical irritability, metabolism, cerebral blood flow and intracranial pressure. We reached the following conclusions: in normocapnia, and with optimal clinical concentrations, this drug remains the best anaesthetic agent since it has no harmful effect either upon metabolism or upon cerebral blood flow. However, in hypertensive cerebral lesions, caution is called for an it seems advisable to combine Enflurane with mild doses of fentanyl. Finally, anaesthesia with enflurane is followed by a rapid and smooth return to consciousness, a valuable factor in neurosurgery where post-operative neurological watching matters very much.
在神经麻醉中，麻醉剂必须符合保护脑完整性所需的某些标准。因此，正是从这样的角度出发，我们重新评估了恩氟烷对皮层兴奋性、代谢、脑血流量和颅内压的影响。我们得出了以下结论：在正常碳酸血症情况下，使用最佳临床浓度时，这种药物仍是最佳麻醉剂，因为它对代谢和脑血流量均无有害影响。然而，在高血压性脑损伤中，需要谨慎使用，似乎建议将恩氟烷与小剂量芬太尼联合使用。最后，使用恩氟烷麻醉后能迅速平稳地恢复意识，这在神经外科手术中是一个很重要的因素，因为术后的神经监护至关重要。
