Engelhardt P, Patzold U
J Neurol. 1975;209(1):45-57. doi: 10.1007/BF00312525.
In the routine cytological examination of the lumbar CSF of 4000 patients, the diagnosis of a tumour was made in 46 cases, most being metastases to the CNS, 20 having meningeal carcinomatosis. There were 9 malignant cerebral tumours of neuroepithelial origin, 2 spinal meningioma and 1 spinal neurinomas. Autochtonous cerebral tumours rarely exfoliate or become differentiated so are more difficult to identify and especially to distinguish from the nonspecific CSF irritation syndrome. On the other hand metastases are morphologically distuinguishable by cell type and the large number of mitoses. Cytological study of the CSF is of great diagnostic value and, in some cases is the only way to make the correct diagnosis.
在对4000例患者的腰椎脑脊液进行常规细胞学检查时，确诊肿瘤46例，多数为中枢神经系统转移瘤，其中20例为脑膜癌病。有9例神经上皮起源的恶性脑肿瘤、2例脊膜瘤和1例脊髓神经鞘瘤。原发性脑肿瘤很少脱落或分化，因此更难识别，尤其难以与非特异性脑脊液刺激综合征相鉴别。另一方面，转移瘤在形态上可通过细胞类型和大量有丝分裂来区分。脑脊液的细胞学研究具有很大的诊断价值，在某些情况下是做出正确诊断的唯一方法。
