Myslobodsky M S, Ackermann R F, Engel J
Pharmacol Biochem Behav. 1979 Sep;11(3):265-71. doi: 10.1016/0091-3057(79)90133-3.
Pretreatment of adult male Sprague-Dawley rats with a single dose of gamma-vinyl GABA (GVG) (1200 mg/kg, IP) or gamma-acetylenic GABA (GAG) (100 mg/kg, IP) did not affect the threshold of metrazol-activated generalized seizures, but increased their duration to the point of status epilepticus. In rats with epilepsy kindled by amygdaloid stimulation, a single dose of GVG (800 mg/kg, IP) and five subsequent daily administrations of GAG (80 mg/kg, IP) tended to reduce the motor manifestations of seizures leaving unaffected their electrographic pattern. The effects of GVG and GAG are attributed in part to decreased arousal. Practical implications of these findings are discussed.
用单剂量的γ-乙烯基γ-氨基丁酸（GVG）（1200毫克/千克，腹腔注射）或γ-乙炔基γ-氨基丁酸（GAG）（100毫克/千克，腹腔注射）对成年雄性斯普拉格-道利大鼠进行预处理，并不影响戊四氮诱发的全身性癫痫发作阈值，但会延长发作持续时间至癫痫持续状态。在经杏仁核刺激点燃癫痫的大鼠中，单剂量的GVG（800毫克/千克，腹腔注射）以及随后连续五天每天给予GAG（80毫克/千克，腹腔注射）倾向于减轻癫痫发作的运动表现，而不影响其脑电图模式。GVG和GAG的作用部分归因于觉醒降低。讨论了这些发现的实际意义。
