Myslobodsky M S, Mintz M, Douglas R
J Neurol. 1980;224(2):111-23. doi: 10.1007/BF00313349.
A single oral dose of Sodium valproate (VPA) given as Epilim (10 mg/kg) inhibited photoconvulsive responses, especially to 15--30 Hz frequency flicker, in seven out of ten patients with photosensitive epilepsy. In addition, in all patients (with an exception of one) the amplitude of the secondary slow negative wave of the visual evoked potentials was reduced 4--5 h after drug administration. However, in five of these patients the normalization of electrocortical reactions to a single flash and flickering light was accompanied by somnolence and fatigue, moderate slowing of EEG background, development of 3 Hz spike-wave activity and (in three patients) augmented response to hyperventilation. In two patients the EEG photoconvulsive discharge was exaggerated by VPA. There VPA effects suggest that photosensitivity and the underlying epileptic condition have overlapping albeit different pathophysiology. The data offer no support for the conclusion that reduced photosensitivity produced by VPA is associated with the therapeutic potency of the drug.
单次口服丙戊酸钠（VPA），以丙戊酸（10mg/kg）的形式给药，在十名光敏性癫痫患者中有七名患者的光惊厥反应受到抑制，尤其是对15 - 30Hz频率闪烁光的反应。此外，在所有患者（除一名患者外）中，给药后4 - 5小时视觉诱发电位的继发性慢负波幅度降低。然而，在这些患者中有五名患者，对单次闪光和闪烁光的皮层电反应恢复正常的同时，出现了嗜睡和疲劳、脑电图背景适度减慢、3Hz棘波活动的出现以及（三名患者）对过度换气的反应增强。在两名患者中，丙戊酸钠使脑电图光惊厥放电加剧。丙戊酸钠的这些作用表明，光敏性和潜在的癫痫状况尽管病理生理学不同，但存在重叠。这些数据不支持丙戊酸钠降低光敏性与该药物治疗效力相关这一结论。
