Blomgren H, Andersson B
Clin Exp Immunol. 1972 Feb;10(2):297-303.
A quantitative analysis of the distribution patterns of intravenously infused Cr-labelled thymus and lymph node cells was carried out. It was observed that only a small fraction of the thymic cells distributed to the lymph nodes of the recipients. These lymph node seeking thymic cells could be enriched by treating the donor mice with cortisone acetate whereas this treatment did not change the distribution pattern of lymph node cells. Thymectomy followed by lethal irradiation and bone marrow reconstitution of the recipients did not change the distribution patterns of normal or cortisone resistant thymic cells. The cells in lymph nodes which home to lymph nodes upon intravenous infusion were found to be thymus-dependent, since they were almost absent in the lymph node cells obtained after thymectomy irradiation and bone marrow protection of the donors. The results indicate that only a small proportion of the cells in the thymus, namely the relatively cortisone resistant cells known to exhibit the cell-bound type of immunological reactivity, behave like recirculating lymphocytes upon infusion into isologous recipients.
对静脉注射铬标记的胸腺细胞和淋巴结细胞的分布模式进行了定量分析。观察到只有一小部分胸腺细胞分布到受体的淋巴结中。通过用醋酸可的松处理供体小鼠，可以富集这些寻找淋巴结的胸腺细胞，而这种处理并没有改变淋巴结细胞的分布模式。受体进行胸腺切除术后再进行致死性照射和骨髓重建，并没有改变正常或对可的松有抗性的胸腺细胞的分布模式。静脉注射后归巢到淋巴结的淋巴结中的细胞被发现是胸腺依赖性的，因为在供体进行胸腺切除、照射和骨髓保护后获得的淋巴结细胞中几乎没有这些细胞。结果表明，胸腺中只有一小部分细胞，即已知表现出细胞结合型免疫反应性的相对抗可的松的细胞，在注入同种异体受体后表现得像再循环淋巴细胞。
