Chohan I S, Singh I, Vermylen J, Verstraete M
Exp Hematol. 1977 Mar;5(2):153-7.
Plasma fibrinolytic activity, as measured by the fibrin-plate method, is enhanced after a single intravenous administration of 40 mg of furosemide. This effect becomes evident within 30 min and a peak response is attained 6 h after i.v. administration. On successive administration of furosemide, the fibrinolytic effect persists and the second peak becomes manifest again after 6 h. Following the parenteral administration of furosemide there is an initial decrease of urinary urokinase excretion which returns to a normal level after 3 to 6 h. Possible mechanisms which may explain the enhanced fibrinolytic activity after furosemide administration are discussed.
通过纤维蛋白平板法测定，单次静脉注射40毫克呋塞米后，血浆纤维蛋白溶解活性增强。这种效应在30分钟内变得明显，静脉注射后6小时达到峰值反应。连续给予呋塞米后，纤维蛋白溶解作用持续存在，第二次峰值在6小时后再次显现。静脉注射呋塞米后，尿激酶排泄量最初会减少，3至6小时后恢复到正常水平。文中讨论了可能解释呋塞米给药后纤维蛋白溶解活性增强的机制。
