Steer A, Lee S S, Stemmermann G N, Yamamoto T, Rhoads G G, Lee K K
Lab Invest. 1979 Dec;41(6):538-45.
Japanese men long resident in Honolulu, Hawaii have significantly more ischemic heart disease but significantly fewer small cardiac scars than men in Hiroshima, Japan. These scars occur in three forms:(1)small scars in the mural myocardium which account for the difference in frequency of small lesions in the two cities and are of uncertain etiology; (2)areas of diffuse fibrosis in the papillary muscles. These are equally frequent in the two cities and are associated with advancing age and sclerosis of papillary muscle arteries; and(3)focal scars in the papillary muscles. These are more frequent in Honolulu than Hiroshima. They are healed infarcts due to ischemic heart disease and are associated with a severe degree of extramural coronary artery atherosclerosis. Small mural myocardial scars, when present, are usually found in multiple sites. Their increased frequency in Hiroshima is not explained by differences in age or heart weight. They are more common in the presence of sclerosis of intramural small arteries, but this association also fails to explain the intercity difference. It is supected that the excess of these small cardiac scars in Hiroshima males reflects past privation. There is no evidence that is is related to A-bomb radiation exposure.
长期居住在夏威夷檀香山的日本男性患缺血性心脏病的比例显著高于日本广岛的男性，但心脏小瘢痕的数量却显著少于广岛男性。这些瘢痕有三种形式：（1）壁层心肌内的小瘢痕，这导致了两个城市小病变频率的差异，其病因不明；（2）乳头肌内的弥漫性纤维化区域。这在两个城市中出现的频率相同，且与年龄增长和乳头肌动脉硬化有关；（3）乳头肌内的局灶性瘢痕。檀香山的这种瘢痕比广岛更常见。它们是缺血性心脏病导致的愈合梗死灶，与严重的壁外冠状动脉粥样硬化有关。壁层心肌小瘢痕若存在，通常出现在多个部位。其在广岛出现频率的增加不能用年龄或心脏重量的差异来解释。它们在壁内小动脉硬化时更常见，但这种关联也无法解释城市间的差异。据推测，广岛男性中这些心脏小瘢痕过多反映了过去的贫困状况。没有证据表明这与原子弹辐射暴露有关。
