霍奇金-赫胥黎轴突。对恒定电流刺激的反应的调制和线性增加。
Hodgkin-Huxley axon. Increased modulation and linearity of response to constant current stimulus.
作者信息
Shapiro B I, Lenherr F K
出版信息
Biophys J. 1972 Sep;12(9):1145-58. doi: 10.1016/S0006-3495(72)86151-4.
Abstract
Repetitive response patterns resembling those of tonic receptors were obtained by increasing the potassium system time constant in the Hodgkin-Huxley (H-H) equations. The increase in time constant varied with membrane potential. Calculated spike frequencies varied linearly with the magnitude of the constant current stimulus; in addition, minimum frequencies were greatly reduced, and the frequency range increased. Modification of the maximum ionic conductances, membrane capacitance, and rate constant voltage dependence was found to vary the minimum frequency, current at that frequency, slope, and over-all modulation of the modified responses.
摘要
通过增加霍奇金-赫胥黎（H-H）方程中的钾系统时间常数，获得了类似于强直感受器的重复反应模式。时间常数的增加随膜电位而变化。计算出的峰值频率与恒定电流刺激的大小呈线性变化；此外，最小频率大大降低，频率范围增加。发现对最大离子电导、膜电容和速率常数电压依赖性的修改会改变最小频率、该频率下的电流、斜率以及修改后反应的整体调制。
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