Marsheck W J, Kraychy S, Muir R D
Appl Microbiol. 1972 Jan;23(1):72-7. doi: 10.1128/am.23.1.72-77.1972.
A process is described for the microbial degradation of cholesterol and plant sterols, to produce androsta-1, 4-diene-3, 17-dione and androst-4-ene-3, 17-dione, by two newly isolated bacteria designated Mycobacterium sp. NRRL B-3683 and Mycobacterium sp. NRRL B-3805. These myocbacteria produce substantial amounts of 17-ketonic compounds without appreciable degradation of the steroid nucleus. No ring degradation inhibitory agents are necessary. The first microbiological production of 20alpha-hydroxymethylpregna-1, 4-dien-3-one is also reported.
描述了一种由两种新分离的细菌，即分枝杆菌属NRRL B - 3683和分枝杆菌属NRRL B - 3805，对胆固醇和植物甾醇进行微生物降解以产生雄甾- 1,4 -二烯- 3,17 -二酮和雄甾- 4 -烯- 3,17 -二酮的过程。这些分枝杆菌能产生大量的17 -酮类化合物，而甾体核没有明显降解。无需使用环降解抑制剂。还报道了首次通过微生物生产20α-羟甲基孕甾- 1,4 -二烯- 3 -酮。
