Mitschke H
Z Gastroenterol. 1979 Aug;17(8):493-502.
A progression in the development of gastritis is not observed following selective proximal vagotomy. Morphometrically, a moderate compensatory foveolar hyperplasia can be noticed in addition to a reduction of parietal cells. Paralleles can be found concerning the ultrastructural alterations of parietal cells following vagotomy or after anticholinergic treatment. They consist in an increase of lamellar osmiophilic bodies, reduction of tubulovesicles, a narrow canalicular lumen and sparse mitochondria. A few years after vagotomy, the parietal cells appear rather unstimulated. After vagotomy, numerous antral G-cells can be demonstrated, with ultrastructural features of increased secretory activity in correlation to raised plasma gastrin levels. This moderate G-cells hyperplasia may, however, already exist preoperatively with the duodenal ulcer. 5 years after vagotomy, there is no pronounced alteration concerning the number of granular or agranular vesicles inside the terminal axons. Experimentally, a degeneration of sympathetic nerves has been described a few days after vagotomy.
选择性近端迷走神经切断术后未观察到胃炎发展进程的进展。形态计量学上，除壁细胞减少外，还可注意到中度的代偿性小凹增生。在迷走神经切断术后或抗胆碱能治疗后壁细胞的超微结构改变方面可发现相似之处。它们表现为嗜锇性板层小体增加、微管泡减少、管腔狭窄和线粒体稀疏。迷走神经切断术后数年，壁细胞显得相当不活跃。迷走神经切断术后，可证实有大量胃窦G细胞，其超微结构特征显示分泌活性增加，与血浆胃泌素水平升高相关。然而，这种中度的G细胞增生在十二指肠溃疡患者术前可能就已存在。迷走神经切断术后5年，终末轴突内颗粒或无颗粒小泡的数量无明显改变。实验中，迷走神经切断术后数天描述了交感神经的退变。
