贲门失弛缓症的去神经部位。
The site of denervation in achalasia.
作者信息
Cohen S, Fisher R, Tuch A
出版信息
Gut. 1972 Jul;13(7):556-8. doi: 10.1136/gut.13.7.556.
Abstract
Lower oesophageal sphincter supersensitivity to gastrin I and cholinergic stimulation has recently been described in patients with achalasia. To determine the pathogenesis of this finding, the lower oesophageal sphincter was tested to a cholinesterase inhibitor, edrophonium chloride. Edrophonium chloride significantly increased the lower oesophageal sphincter pressure both in normal subjects and in patients with achalasia. The preservation of this response in the presence of denervation supersensitivity suggested intact postganglionic cholinergic nerves and, thus, a preganglionic site of denervation in achalasia.
摘要
最近有研究表明，贲门失弛缓症患者的食管下括约肌对胃泌素I和胆碱能刺激超敏。为了确定这一发现的发病机制，对食管下括约肌进行了胆碱酯酶抑制剂氯化腾喜龙试验。氯化腾喜龙显著增加了正常受试者和贲门失弛缓症患者的食管下括约肌压力。在存在去神经超敏的情况下这种反应得以保留，提示节后胆碱能神经完整，因此贲门失弛缓症的去神经部位在节前。
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